Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Glutathione: Why is it important for detox & how to improve the amount in your body RealTime Laboratories What is Mast Cell Activation Syndrome? Longevity Health How Mast Cells Contribute to Autoimmune Brain Disorders Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione.