Can you donate blood if you smoke? Can You Donate Blood If You Smoke? Our Blood Institute Does Nicotine Free Vaping Affect Your Blood Vessels? What Science Tells Us Medic Pro Smoking and vaping don't affect your eligibility to donate. Become a donor and give life today. Vaping is as bad as smoking and it significantly decreases lifespan. Vaping contains ultrafine particles, volatile organic compounds and aldehydes that promote inflammation and damage heart and lungs. Here are scientific evidence