Why Does Glutathione Cause Acne Breakouts? Glamorous Dubai Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Root Cause of Hair Loss + How to Combat It Nikki Yelton RD Tylenol and Alcohol: The Dangers of Polydrug Abuse Tylenol and Glutathione: A Closer Look At Their Relationship