Heres why you should avoid Tylenol , First of all, it is full of colorful dyes, sugars, and additives., But the main reason is it depletes glutathione., Glutathione is one of the most Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it Sex differences in glutathione metabolism and acetaminophen toxicity Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums