Dental Update Malignant oral melanoma: how to spot it and how it is managed Dental Update Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Oral melanotic macule" Pigmented Lesions of the Oral Cavity Oral and Maxillofacial Surgery Clinics Viral 'Barbie drug' for tanning can cause brain swelling and even cancer, experts warn