Although G6PD deficiency, which can cause problems in red blood cells upon certain triggers, is the most common human enzyme defect, affecting over 400 million people, including over 1 in 10 Black G6pd glucose6phosphate dehydrogenase pathway vector illustration graphic Premium Vector Diabetes causes inhibition of glucose 6 phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex American Journal of Physiology Renal Physiology American Physiological Society Glucose 6 Phosphate Dehydrogenase an overview ScienceDirect Topics Frontiers The global role of G6PD in infection and immunity