This is a very rare case of metastatic oral mucosal melanoma to the colon with an unusual presentation mimicking melanosis coli. The colonoscopy findings show no mass effect but multiple hyperpigmented lesions Pigmentation (melanosis) of the colon Stock Image C009 6107 Science Photo Library Endoscopic findings of different grades and severities of melanosis Download Scientific Diagram Melanosis coli Wikipedia Leopard skin appearance on colonoscopy. Melanosis coli is a condition characterized by dark brown or black pigmentation of the colon lining, often resulting from the prolonged use of anthraquinone laxatives like senna