What is Acetaminophen Uses, Dangers, Risks, & More Rubicon Tylenol And Glutathione Invigor Medical USMLE Step 2 CK Question of the Day: Altered Mental State After Over the counter pain reliever and Prescription Hydrocodone acetaminophen Osmosis Blog Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Overdose Concise Medical Knowledge