Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Paracetamol Induced Hepatotoxicity , Overdose NAPQI formation Glutathione depletion Liver cell necrosis. Early N acetylcysteine (NAC) can save the liver., #Pharmacology #mbbs #Hepatotoxicity PDF) A review of the evidence concerning hepatic glutathione depletion and susceptibility to liver toxicity after paracetamol overdose Frontiers MitochondrialLysosomal Axis in Acetaminophen Hepatotoxicity File:Paracetamol metabolism.svg Wikimedia Commons
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glutathione depletion paracetamol The Metabolism of Acetaminophen and the Synthesis of Glutathione