The parent compounds of acetaminophen (US market in 1955 in the US as Tylenol and other products) were first discovered in 1886 (acetanilide) and 1887 (phenacetin). These were the earliest synthetic fever Just say NO to Tylenol (Acetaminophen linked to autism?) Naturopathic Pediatrics Does Tylenol Cause Autism? Where the Idea Came From Wholehealthweb Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Jenny McCarthy's Glutathione and Tylenol Claims: Medical Toxicologist Weighs In