Asprin Mechanism of Action: Antiplatelet Activity Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Essential Glutathione Optimal Health Systems Glutathione ascorbate cycle Wikipedia Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin New England Journal of Medicine
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