This #GUTRecentAdvancesInBasicScience review synthesises emerging evidence linking the microbiome to cardiovascular disease, highlighting shared inflammatory and metabolic pathways. Fusco et al. present Gut microbiota and atherosclerosis access it JCI l Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans TMAO Is Both a Biomarker and a Renal Toxin Circulation Research Pathobiological Relationship of Excessive Dietary Intake of Choline L Carnitine: A TMAO Precursor Associated Aggravation in Heart Failure in Sarcopenic Patients The Carnitine butyrobetaine trimethylamine N oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis Atherosclerosis