Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness?