Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification This graphic highlights the critical role of glutathione in protecting Download Scientific Diagram Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Liver specific Bcl3 Knockout Alleviates Acetaminophen induced Liver Injury by Activating Nrf2 Pathway in Male Mice Cellular and Molecular Gastroenterology and Hepatology Tumor targeted glutathione oxidation catalysis with ruthenium nanoreactors against hypoxic osteosarcoma Nature Communications