Acetaminophen Pathway (toxic doses), Pharmacokinetics Tylenol Glutathione Kizer Wellness LLC A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Metabolism of acetaminophen (paracetamol) in plantstwo independent pathways result in the formation of a glutathione and a glucose conjugate Environmental Science and Pollution Research Springer Nature Link GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY