Most people learn about senescent cells from a podcast. I learned about them the hard way after pushing my body through the Grand Goals campaign and realizing that physical achievement doesn't mean Molecular modelling of the FOXO4 TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells eBioMedicine 2022 Lupus Highlight Therapeutic Targeting of Senescent Cells in Lupus, Lupus Research Program, Congressionally Directed Medical Research Programs Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment npj Aging The costs and benefits of senotherapeutics for human health The Lancet Healthy Longevity
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foxo4-dri senolytic human trial The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI