Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Acetaminophen Depletes Glutathione Essential Formulas I've posted this every year for 7 years. PSA please share. The horror stories from Tylenol (Acetaminophen) usage for children are hard to digest literally. The way my mind Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA