Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development. PDF] Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma Semantic Scholar Acetaminophen (Paracetamol) Springer Nature Link Figure 1 from Acetaminophen toxicity and 5 oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP depleting futile cycle and the other a useful cycle. Semantic Scholar