Glutathione IV for Liver Detox: Support & Benefits AZ IV Medics The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification Liver injury induced by paracetamol and challenges associated with intentional and unintentional use