How Glutathione IV Therapy Supports Natural Detoxification AZ IV Medics Current Insights into Glutathione Depletion in Adult Septic Patients Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy ACS Omega Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.