Acetylcysteine for Acetaminophen Poisoning New England Journal of Medicine Sex differences in glutathione metabolism and acetaminophen toxicity Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Acetaminophen, also known as Tylenol, is used to help with pain & to reduce fever. However, taking too much acetaminophen can be harmful to the liver which filters out toxins & Acetaminophen Anesthesia Key