Glutathione System from Cyanobacteria to Higher Eukaryotes Encyclopedia MDPI Frontiers Glutathione and mitochondria Glutathione (GSH), the body's primary intracellular antioxidant, plays a fundamental role in maintaining redox balance and detoxification. In normal physiology, this is protective. However, in oncology, the picture becomes more nuanced. Emerging Glutathione: Physiological and Clinical Relevance Vitawell Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation