What to Know About Electronic Cigarettes (E Cigarettes) Globus Pharyngeus Possible causes include smoking vaping, stress anxiety, thyroid nodules, tight throat muscles, acid reflux, or poor esophageal muscle function. (Jama network) Did you know smokingand even vapingcan cause heartburn and worsen acid reflux? The latest research shows both habits increase your risk of GERD, but the good news is quitting can make A Single Vape Raises Oxidative Stress Levels in Nonsmokers Respiratory Therapy Did you know smokingand even vapingcan cause heartburn and worsen acid reflux? The latest research shows both habits increase your risk of GERD, but the good news is quitting can make