Frontiers Non Canonical Effects of ACTH: Insights Into Adrenal Insufficiency Ipamorelin and CJC 1295 are almost always discussed together in research circles, and the reason comes down to receptor pharmacology. The two peptides work through entirely different but complementary mechanisms that produce a Prolactin, a hormone that can affect reproductive capacity Adrenal function and dysfunction in critically ill patients Nature Reviews Endocrinology The most common GH releasing peptides: , Ipamorelin A ghrelin receptor agonist that triggers short pulses of growth hormone release from the pituitary with minimal effects on cortisol, prolactin, or