Frontiers Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy Morphology of melanocytic lesions in situ Scientific Reports Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Genital Melanotic Macules DoveMed Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review